For patients 12 years and older with chronic graft-versus-host disease (chronic GVHD) after 2 prior systemic treatments did not work.

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For US Residents Only

What happens in your body when you have chronic GVHD?

Chronic GVHD causes your immune system to become unbalanced. In people with chronic GVHD, the immune system overreacts, creating too many of some cells and molecules, and not enough of others. This leads to inflammation (swelling) and fibrosis (hardening, scarring).

pink icons showing that an unbalanced immune system caused by chronic GVHD leads to inflammation and fibrosis

INFLAMMATION

is swelling that occurs because your body is trying to protect itself.

Inflammation that goes on for a long time, like in chronic GVHD, may cause damage to your body.

FIBROSIS

is the growth of scar tissue that hardens and keeps your organs from working properly.

In some people, fibrosis happens when inflammation goes on for a long time. It is also possible for scar tissue to form without any inflammation.

People with chronic GVHD face many challenges.

See people discuss the challenges of living with chronic GVHD


Chronic GVHD may affect many different parts of your body

Common symptoms of chronic GVHD include

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Skin rashes, changes in skin color and skin thickening or tightening

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Chronic cough, shortness of breath or difficulty breathing

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Stiff joints and trouble using your fingers, hands, elbows, knees or ankles


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Nausea, vomiting, diarrhea or loss of appetite

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Dry eyes or vision changes

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General decline in health, including fatigue

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Sensitivity to food, irritation and dryness of the mouth and difficulty swallowing food

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Abnormal liver function, measured by various tests

pink hand with skin rash icon

Skin rashes, changes in skin color and skin thickening or tightening

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Stiff joints and trouble
using your fingers,
hands, elbows, knees
or ankles

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Dry eyes or vision changes

pink icon of open mouth with teeth

Sensitivity to food, irritation and dryness of the mouth and difficulty swallowing food

pink lungs icon

Chronic cough, shortness of breath or difficulty breathing

pink circular icon of a human silhouette with circles near the digestive system

Nausea, vomiting, diarrhea or loss of appetite

pink desending line graph icon

General decline in
health, including fatigue

pink liver icon

Abnormal liver function, measured by various tests

Some people also have

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Lack of energy

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Reduced ability to do daily tasks

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Lack of energy

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Reduced ability to do daily tasks

Management of chronic GVHD


Management of chronic GVHD is based on which of your organs are affected, the severity of your symptoms and the impact of the disease on your daily life.

Medicines that treat chronic GVHD


Health care providers may try different medicines, including immunosuppressants, to help treat chronic GVHD. However, for some people that might not be enough, and they will need a different approach.

If you have chronic GVHD and are still experiencing symptoms, talk with your health care team about your treatment options.

See how REZUROCK
works differently >>

GVHD, graft-versus-host disease.

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