What happens in your body when you have chronic GVHD?

Chronic GVHD causes your immune system to become unbalanced. In people with chronic GVHD, the immune system overreacts, creating too many of some cells and not enough of others. This leads to inflammation (swelling) and fibrosis (scarring).

pink icons showing that an unbalanced immune system caused by chronic GVHD leads to inflammation and fibrosis

INFLAMMATION

is swelling that occurs because your body is trying to protect itself.

Inflammation that goes on for a long time, like in chronic GVHD, may cause damage to your body.

FIBROSIS

is the growth of scar tissue that hardens and keeps your organs from working properly.

In some people, fibrosis happens when inflammation goes on for a long time. It is also possible for scar tissue to form without any inflammation.

People with chronic GVHD face many challenges.

Chronic GVHD may affect many different parts of your body

Symptoms of chronic GVHD include

pink circular icon of an arm with a skin rash

Painful skin rashes,
along with skin
thickening or tightening

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Stiff joints and trouble
using your fingers,
hands, elbows, knees
or ankles

pink circular icon of an eye

Dry eyes or vision changes

pink circular icon of the lungs

Chronic cough, shortness of breath or difficulty breathing

pink circular icon of a human silhouette with circles near the digestive system

Nausea, vomiting, diarrhea or loss of appetite

pink circular icon of a descending line

General decline in
health, including fatigue

People with chronic GVHD also struggle with quality-of-life issues

pink and white circular icon of 2 people's side profiles, with a positive symbol in one and a negative symbol in the other

Increased cases of depression or anxiety

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Social interaction problems

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Lack of energy

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Reduced ability to
carry
out daily tasks

If you’re on medicine but continue to have these symptoms, talk with your health care team. REZUROCK may be right for you.

See how REZUROCK is a

different kind of treatment

Watch videos

to see how people cope with chronic GVHD

GVHD, graft-versus-host disease.

USE

REZUROCKTM (belumosudil) is a prescription medicine used to treat adults and children 12 years of age and older with chronic graft-versus-host disease (chronic GVHD) after you have received at least 2 prior treatments (systemic therapy) and they did not work. It is not known if REZUROCK is safe and effective in children less than 12 years old.

IMPORTANT SIDE EFFECT INFORMATION

Before taking REZUROCK, tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney or liver problems.
  • are pregnant or plan to become pregnant. REZUROCK can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with REZUROCK. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with REZUROCK.
  • - Females who can become pregnant should use effective birth control during treatment with REZUROCK and for at least 1 week after the last dose.
  • - Males with female partners who can become pregnant should use effective birth control during treatment with REZUROCK and for at least 1 week after the last dose.
  • are breastfeeding or plan to breastfeed. It is not known if REZUROCK passes into breast milk. Do not breastfeed during treatment with REZUROCK and for at least 1 week after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REZUROCK may affect the way other medicines work, and other medicines may affect the way REZUROCK works.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take REZUROCK?

  • Take REZUROCK exactly as your healthcare provider tells you to take it.
  • Do not change your dose or stop taking REZUROCK without first talking to your healthcare provider.
  • Take REZUROCK 1 time a day with a meal.
  • Take REZUROCK at about the same time each day.
  • Swallow REZUROCK tablets whole with a glass of water.
  • Do not cut, crush, or chew REZUROCK tablets.
  • Your healthcare provider will do blood tests to check your liver at least 1 time a month during treatment with REZUROCK.
  • If you miss a dose of REZUROCK, take it as soon as you remember on the same day. Take your next dose of REZUROCK at your regular time on the next day. Do not take extra doses of REZUROCK to make up for a missed dose.
  • If you take too much REZUROCK, call your healthcare provider or go to the nearest hospital emergency room right away.

What are the possible side effects of REZUROCK?

The most common side effects of REZUROCK include:

  • infections
  • tiredness or weakness
  • nausea
  • diarrhea
  • shortness of breath
  • cough
  • swelling
  • bleeding
  • stomach (abdominal) pain
  • muscle or bone pain
  • headache
  • high blood pressure

Your healthcare provider may change your dose of REZUROCK, temporarily stop, or permanently stop treatment with REZUROCK if you have certain side effects.

REZUROCK may affect fertility in males and females. Talk to your healthcare provider if this is a concern for you.

These are not all the possible side effects of REZUROCK. Call your doctor for medical advice about side effects.

Please see full Prescribing Information.

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. You may also contact Kadmon Pharmaceuticals, LLC, at 1-877-377-7862 to report side effects.

pink circular icon with plus sign

Use

REZUROCKTM (belumosudil) is a prescription medicine used to treat adults and children 12 years of age and older with chronic graft-versus-host disease (chronic GVHD)

IMPORTANT SIDE EFFECT INFORMATION Before taking REZUROCK, tell your healthcare provider about all of your medical conditions, including if you: pink circular icon with plus sign

Use & Important side effect information

REZUROCKTM (belumosudil) is a prescription medicine used to treat adults and children