Chronic GVHD causes your immune system to become unbalanced. In people with chronic GVHD, the immune system overreacts, creating too many of some cells and not enough of others. This leads to inflammation (swelling) and fibrosis (scarring).
is swelling that occurs because your body is trying to protect itself.
Inflammation that goes on for a long time, like in chronic GVHD, may cause damage to your body.
is the growth of scar tissue that hardens and keeps your organs from working properly.
In some people, fibrosis happens when inflammation goes on for a long time. It is also possible for scar tissue to form without any inflammation.
Symptoms of chronic GVHD include
Painful skin rashes,
along with skin
thickening or tightening
Stiff joints and trouble
using your fingers,
hands, elbows, knees
Dry eyes or vision changes
Chronic cough, shortness of breath or difficulty breathing
Nausea, vomiting, diarrhea or loss of appetite
General decline in
health, including fatigue
Increased cases of depression or anxiety
Social interaction problems
Lack of energy
Reduced ability to
out daily tasks
If you’re on medicine but continue to have these symptoms, talk with your health care team. REZUROCK may be right for you.
GVHD, graft-versus-host disease.
REZUROCKTM (belumosudil) is a prescription medicine used to treat adults and children 12 years of age and older with chronic graft-versus-host disease (chronic GVHD) after you have received at least 2 prior treatments (systemic therapy) and they did not work. It is not known if REZUROCK is safe and effective in children less than 12 years old.
Before taking REZUROCK, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REZUROCK may affect the way other medicines work, and other medicines may affect the way REZUROCK works.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should I take REZUROCK?
What are the possible side effects of REZUROCK?
The most common side effects of REZUROCK include:
Your healthcare provider may change your dose of REZUROCK, temporarily stop, or permanently stop treatment with REZUROCK if you have certain side effects.
REZUROCK may affect fertility in males and females. Talk to your healthcare provider if this is a concern for you.
These are not all the possible side effects of REZUROCK. Call your doctor for medical advice about side effects.
Please see full Prescribing Information.
You are encouraged to report side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. You may also contact Kadmon Pharmaceuticals, LLC, at 1-877-377-7862 to report side effects.
REZUROCKTM (belumosudil) is a prescription medicine used to treat adults and children 12 years of age and older with chronic graft-versus-host disease (chronic GVHD)
REZUROCKTM (belumosudil) is a prescription medicine used to treat adults and children