For patients 12 years and older with chronic graft-versus-host disease (chronic GVHD) after 2 prior systemic treatments did not work.
    Read full Important Safety Information

Living with chronic GVHD

Living with chronic graft-versus-host disease (chronic GVHD) can be overwhelming for people who are directly impacted by the disease and for their caregivers.

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What happens in your body when you have chronic GVHD?


Chronic GVHD CAUSES YOUR IMMUNE SYSTEM TO BECOME UNBALANCED. In people with chronic GVHD, the immune system overreacts, creating too many of some cells and molecules, and not enough of others. This leads to inflammation (swelling) and fibrosis (hardening, scarring).

Pink icons showing that an unbalanced immune system leads to inflammation and fibrosis

INFLAMMATION

is swelling that occurs because your body is trying to protect itself.

Inflammation that goes on for a long time, like in chronic GVHD, may cause damage to your body.

FIBROSIS

is the growth of scar tissue that hardens and keeps your organs from working properly.

In some people, fibrosis happens when inflammation goes on for a long time. It is also possible for scar tissue to form without any inflammation.

People with chronic GVHD face many challenges.

See people discuss the challenges of living with chronic GVHD

Bringing Clarity to Chronic GVHD
The Psychological Impact of Chronic GVHD
The Impact of Chronic GVHD on Quality of Life

Chronic GVHD may affect many different parts of your body

Common symptoms of chronic GVHD include

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Skin rashes, changes in skin color and skin thickening or tightening

Pink lungs icon

Chronic cough, shortness of breath or difficulty breathing

Pink bent knee joint icon

Stiff joints and trouble using your fingers, hands, elbows, knees or ankles

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Nausea, vomiting, diarrhea or loss of appetite

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Dry eyes or vision changes

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General decline in health, including fatigue

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Sensitivity to food, irritation and dryness of the mouth and difficulty swallowing food

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Abnormal liver function, measured by various tests

Some people also have

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Lack of energy

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Reduced ability to do daily tasks

Management of chronic GVHD


Management of chronic GVHD is based on which of your organs are affected, the severity of your symptoms and the impact of the disease on your daily life.

Medicines that treat chronic GVHD


Health care providers may try different medicines, including immunosuppressants, to help treat chronic GVHD. However, for some people that might not be enough, and they will need a different approach.

If you have chronic GVHD and are still experiencing symptoms, talk with your health care team about your treatment options.

GET ANSWERS

to commonly asked questions about chronic GVHD and REZUROCK.

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GVHD, graft-versus-host disease.

USE

REZUROCK® (belumosudil) is a prescription medicine used to treat adults and children 12 years of age and older with chronic graft-versus-host disease (chronic GVHD) after you have received at least 2 prior treatments (systemic therapy) and they did not work. It is not known if REZUROCK is safe and effective in children less than 12 years old.

IMPORTANT SAFETY INFORMATION
IMPORTANT SAFETY INFORMATION

Before taking REZUROCK, tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney or liver problems.
  • are pregnant or plan to become pregnant. REZUROCK can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with REZUROCK. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with REZUROCK.
    • Females who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
    • Males with female partners who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
  • are breastfeeding or plan to breastfeed. It is not known if REZUROCK passes into breast milk. Do not breastfeed during treatment with REZUROCK and for 1 week after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REZUROCK may affect the way other medicines work, and other medicines may affect the way REZUROCK works.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take REZUROCK?

  • Take REZUROCK exactly as your healthcare provider tells you to take it.
  • Do not change your dose or stop taking REZUROCK without first talking to your healthcare provider.
  • Take REZUROCK 1 time a day with a meal.
  • Take REZUROCK at about the same time each day.
  • Swallow REZUROCK tablets whole with a glass of water.
  • Do not cut, crush, or chew REZUROCK tablets.
  • Your healthcare provider will do blood tests to check your liver at least 1 time a month during treatment with REZUROCK.
  • If you miss a dose of REZUROCK, take it as soon as you remember on the same day. Take your next dose of REZUROCK at your regular time on the next day. Do not take extra doses of REZUROCK to make up for a missed dose.
  • If you take too much REZUROCK, call your healthcare provider or go to the nearest hospital emergency room right away.

What are the possible side effects of REZUROCK?

The most common side effects of REZUROCK include:

  • infections
  • tiredness or weakness
  • nausea
  • diarrhea
  • shortness of breath
  • cough
  • swelling
  • bleeding
  • stomach (abdominal) pain
  • muscle or bone pain
  • headache
  • high blood pressure

Your healthcare provider may change your dose of REZUROCK, temporarily stop, or permanently stop treatment with REZUROCK if you have certain side effects.

REZUROCK may affect fertility in males and females. Talk to your healthcare provider if this is a concern for you.

These are not all the possible side effects of REZUROCK. Call your doctor for medical advice about side effects.

Please see full Prescribing Information.

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. You may also contact Kadmon Pharmaceuticals, LLC, a Sanofi company, at 1-800-633-1610 to report side effects.

           
IMPORTANT SAFETY INFORMATION
IMPORTANT SAFETY INFORMATION

Before taking REZUROCK, tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney or liver problems.
  • are pregnant or plan to become pregnant. REZUROCK can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with REZUROCK. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with REZUROCK.
    • Females who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
    • Males with female partners who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
  • are breastfeeding or plan to breastfeed. It is not known if REZUROCK passes into breast milk. Do not breastfeed during treatment with REZUROCK and for 1 week after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REZUROCK may affect the way other medicines work, and other medicines may affect the way REZUROCK works.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take REZUROCK?

  • Take REZUROCK exactly as your healthcare provider tells you to take it.
  • Do not change your dose or stop taking REZUROCK without first talking to your healthcare provider.
  • Take REZUROCK 1 time a day with a meal.
  • Take REZUROCK at about the same time each day.
  • Swallow REZUROCK tablets whole with a glass of water.
  • Do not cut, crush, or chew REZUROCK tablets.
  • Your healthcare provider will do blood tests to check your liver at least 1 time a month during treatment with REZUROCK.
  • If you miss a dose of REZUROCK, take it as soon as you remember on the same day. Take your next dose of REZUROCK at your regular time on the next day. Do not take extra doses of REZUROCK to make up for a missed dose.
  • If you take too much REZUROCK, call your healthcare provider or go to the nearest hospital emergency room right away.

What are the possible side effects of REZUROCK?

The most common side effects of REZUROCK include:

  • infections
  • tiredness or weakness
  • nausea
  • diarrhea
  • shortness of breath
  • cough
  • swelling
  • bleeding
  • stomach (abdominal) pain
  • muscle or bone pain
  • headache
  • high blood pressure

Your healthcare provider may change your dose of REZUROCK, temporarily stop, or permanently stop treatment with REZUROCK if you have certain side effects.

REZUROCK may affect fertility in males and females. Talk to your healthcare provider if this is a concern for you.

These are not all the possible side effects of REZUROCK. Call your doctor for medical advice about side effects.

Please see full Prescribing Information.

You are encouraged to report side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. You may also contact Kadmon Pharmaceuticals, LLC, a Sanofi company, at 1-800-633-1610 to report side effects.