What causes chronic GVHD?
During the transplant, you received stem cells from a donor. These donated stem cells are called the “graft,” and your body is known as the “host.” The graft forms a new immune system in your body. Sometimes, this new immune system does not fully recognize your body’s cells. It may see them as a threat and start to attack them. When this happens, chronic GVHD can develop.
In fact, about half of people who receive a blood stem cell transplant from a donor develop chronic GVHD. When chronic GVHD develops, it causes your immune system to become unbalanced, creating too many of some cells and molecules, and not enough of others, which can harm different parts of your body. The imbalance in the immune system caused by chronic GVHD can lead to inflammation (swelling) and fibrosis (hardening and scarring), which can damage your organs.
Inflammation and fibrosis: the two challenges of chronic GVHD
Hear from others living with chronic GVHD
Bringing Clarity to Chronic GVHD
Patient stories reflect the real-life experiences of persons diagnosed with cGVHD. However, individual experiences may vary. These patients were compensated for their time creating these videos.
ON-SCREEN TEXT: BRINGING CLARITY TO cGVHD, chronic graft-versus-host disease.
ON-SCREEN TEXT: If cGVHD were an animal…
ON-SCREEN TEXT: Vera, age 51 years, diagnosed with cGVHD in 2018
VERA: If chronic GVHD were an animal, it would be a rhino. Rhinos are very scary to me. They’ve got tough skin. I associate that with the hardening of the skin on my legs.
ON-SCREEN TEXT: See what others had to say in a little bit.
ON-SCREEN TEXT: Understanding cGVHD can be almost as challenging as living with the disease.
ON-SCREEN TEXT: How would you describe cGVHD in 3 words?
ON-SCREEN TEXT: Russ, age 60 years, diagnosed with cGVHD in 2018
RUSS: Fatigue. Constant discomfort. Pain.
ON-SCREEN TEXT: Jo-Anne, caregiver
JO-ANNE: Mine are so shallow compared with his—nuisance, disappointing and unending.
ON-SCREEN TEXT: Jennifer, age 47 years, diagnosed with cGVHD in 2018
JENNIFER: Constant, vigorous and debilitating.
ON-SCREEN TEXT: Gail, age 72 years, diagnosed with cGVHD in 2018
GAIL: Life-altering, fatiguing and challenging.
ON-SCREEN TEXT: Marlyn, age 47 years, diagnosed with cGVHD in 2018
MARLYN: Fatigue, dryness and long-term.
VERA: Treatable, painful and life-changing.
ON-SCREEN TEXT: Explaining cGVHD to loved ones can be complex, and some cope with it better than others.
JENNIFER: I feel like a broken record, trying to educate people and remind them. You see makeup or hair, but you don't see the bald head from treatments. It's not what it seems. It's a mask, if you will.
MARLYN: How do I explain what I'm going through to my children or my family? I explain it to them as if it's just something that I have to go through post transplant.
RUSS: One of the research nurses had given us some tips about how to measure progress, and that helped me a lot. In going back to work, it's not whether or not I was better this week than last week. It’s was my week better than 3 months ago. Even with the symptoms of chronic GVHD, I was able to get back to work full-time. I just had to phase it in slowly over time.
ON-SCREEN TEXT: If cGVHD were an animal, what would it be?
MARLYN: I’d describe it as a chameleon, because it changes color, location and severity. It changes itself every day. It has good days and bad days.
JO-ANNE: To me, it's like a fly that’s always hanging around. It can irritate you to death and buzz you. Sometimes it leaves you alone, and you don’t notice it as much. It can really make you feel like you just can't relax. It's there in your life, and you can't always go about doing what you want.
JENNIFER: Chronic GVHD would definitely be a zebra, because its stripes are mysterious and nobody really understands it. But it's fascinating, in and of itself. It's a by-product of a cure for a deadly disease. So, it's beautiful in 1 sense because it helps me in a weird way.
GAIL: I would choose a cat. We had a pet cat who would climb on my lap. I would stroke her, and she’d purr and purr. Then, out of the blue, she’d bite me.
RUSS: I would call it lice. It's annoying, embarrassing and hard to get rid of.
ON-SCREEN TEXT: Understanding cGVHD is just one of many challenges for patients
ON-SCREEN TEXT: Special thanks to BMT Infonet and our video participants for their support of this project
Patients were compensated for their time
© 2022 Kadmon Pharmaceuticals, LLC. All Rights Reserved.
MAT-US-2200728-v1.0-02/2022
cGVHD, chronic graft-versus-host disease; GVHD, graft-versus-host disease.
USE AND IMPORTANT SAFETY INFORMATION
REZUROCK® (belumosudil) is a prescription medicine used to treat adults and children 12 years of age and older with chronic graft-versus-host disease (chronic GVHD) after you have received at least 2 prior treatments (systemic therapy) and they did not work. It is not known if REZUROCK is safe and effective in children less than 12 years old.
Before taking REZUROCK, tell your healthcare provider about all of your medical conditions, including if you:
have kidney or liver problems.
are pregnant or plan to become pregnant. REZUROCK can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with REZUROCK. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with REZUROCK.
Females who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
Males with female partners who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
are breastfeeding or plan to breastfeed. It is not known if REZUROCK passes into breast milk. Do not breastfeed during treatment with REZUROCK and for 1 week after the last dose.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REZUROCK may affect the way other medicines work, and other medicines may affect the way REZUROCK works.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should I take REZUROCK?
Take REZUROCK exactly as your healthcare provider tells you to take it.
Do not change your dose or stop taking REZUROCK without first talking to your healthcare provider.
Take REZUROCK 1 time a day with a meal.
Take REZUROCK at about the same time each day.
Swallow REZUROCK tablets whole with a glass of water.
Do not cut, crush, or chew REZUROCK tablets.
Your healthcare provider will do blood tests to check your liver at least 1 time a month during treatment with REZUROCK.
If you miss a dose of REZUROCK, take it as soon as you remember on the same day. Take your next dose of REZUROCK at your regular time on the next day. Do not take extra doses of REZUROCK to make up for a missed dose.
If you take too much REZUROCK, call your healthcare provider or go to the nearest hospital emergency room right away.
What are the possible side effects of REZUROCK?
The most common side effects of REZUROCK include:
infections
tiredness or weakness
nausea
diarrhea
shortness of breath
cough
swelling
bleeding
stomach (abdominal) pain
muscle or bone pain
headache
high blood pressure
Your healthcare provider may change your dose of REZUROCK, temporarily stop, or permanently stop treatment with REZUROCK if you have certain side effects.
REZUROCK may affect fertility in males and females. Talk to your healthcare provider if this is a concern for you.
These are not all the possible side effects of REZUROCK. Call your doctor for medical advice about side effects.
Please see full Prescribing Information.
You are encouraged to report side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. You may also contact Kadmon Pharmaceuticals, LLC, a Sanofi Company, at 1-800-633-1610 to report side effects.
USE AND IMPORTANT SAFETY INFORMATION
REZUROCK® (belumosudil) is a prescription medicine used to treat adults and children 12 years of age and older with chronic graft-versus-host disease (chronic GVHD) after you have received at least 2 prior treatments (systemic therapy) and they did not work. It is not known if REZUROCK is safe and effective in children less than 12 years old.
Before taking REZUROCK, tell your healthcare provider about all of your medical conditions, including if you:
have kidney or liver problems.
are pregnant or plan to become pregnant. REZUROCK can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with REZUROCK. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with REZUROCK.
Females who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
Males with female partners who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
are breastfeeding or plan to breastfeed. It is not known if REZUROCK passes into breast milk. Do not breastfeed during treatment with REZUROCK and for 1 week after the last dose.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REZUROCK may affect the way other medicines work, and other medicines may affect the way REZUROCK works.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should I take REZUROCK?
Take REZUROCK exactly as your healthcare provider tells you to take it.
Do not change your dose or stop taking REZUROCK without first talking to your healthcare provider.
Take REZUROCK 1 time a day with a meal.
Take REZUROCK at about the same time each day.
Swallow REZUROCK tablets whole with a glass of water.
Do not cut, crush, or chew REZUROCK tablets.
Your healthcare provider will do blood tests to check your liver at least 1 time a month during treatment with REZUROCK.
If you miss a dose of REZUROCK, take it as soon as you remember on the same day. Take your next dose of REZUROCK at your regular time on the next day. Do not take extra doses of REZUROCK to make up for a missed dose.
If you take too much REZUROCK, call your healthcare provider or go to the nearest hospital emergency room right away.
What are the possible side effects of REZUROCK?
The most common side effects of REZUROCK include:
infections
tiredness or weakness
nausea
diarrhea
shortness of breath
cough
swelling
bleeding
stomach (abdominal) pain
muscle or bone pain
headache
high blood pressure
Your healthcare provider may change your dose of REZUROCK, temporarily stop, or permanently stop treatment with REZUROCK if you have certain side effects.
REZUROCK may affect fertility in males and females. Talk to your healthcare provider if this is a concern for you.
These are not all the possible side effects of REZUROCK. Call your doctor for medical advice about side effects.
Please see full Prescribing Information.
You are encouraged to report side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. You may also contact Kadmon Pharmaceuticals, LLC, a Sanofi Company, at 1-800-633-1610 to report side effects.
USE AND IMPORTANT SAFETY INFORMATION
REZUROCK® (belumosudil) is a prescription medicine used to treat adults and children 12 years of age and older with chronic graft-versus-host disease (chronic GVHD) after you have received at least 2 prior treatments (systemic therapy) and they did not work. It is not known if REZUROCK is safe and effective in children less than 12 years old.
Before taking REZUROCK, tell your healthcare provider about all of your medical conditions, including if you:
have kidney or liver problems.
are pregnant or plan to become pregnant. REZUROCK can harm your unborn baby. If you are able to become pregnant, your healthcare provider will do a pregnancy test before starting treatment with REZUROCK. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment with REZUROCK.
Females who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
Males with female partners who can become pregnant should use effective birth control during treatment with REZUROCK and for 1 week after the last dose.
are breastfeeding or plan to breastfeed. It is not known if REZUROCK passes into breast milk. Do not breastfeed during treatment with REZUROCK and for 1 week after the last dose.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REZUROCK may affect the way other medicines work, and other medicines may affect the way REZUROCK works.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should I take REZUROCK?
Take REZUROCK exactly as your healthcare provider tells you to take it.
Do not change your dose or stop taking REZUROCK without first talking to your healthcare provider.
Take REZUROCK 1 time a day with a meal.
Take REZUROCK at about the same time each day.
Swallow REZUROCK tablets whole with a glass of water.
Do not cut, crush, or chew REZUROCK tablets.
Your healthcare provider will do blood tests to check your liver at least 1 time a month during treatment with REZUROCK.
If you miss a dose of REZUROCK, take it as soon as you remember on the same day. Take your next dose of REZUROCK at your regular time on the next day. Do not take extra doses of REZUROCK to make up for a missed dose.
If you take too much REZUROCK, call your healthcare provider or go to the nearest hospital emergency room right away.
What are the possible side effects of REZUROCK?
The most common side effects of REZUROCK include:
infections
tiredness or weakness
nausea
diarrhea
shortness of breath
cough
swelling
bleeding
stomach (abdominal) pain
muscle or bone pain
headache
high blood pressure
Your healthcare provider may change your dose of REZUROCK, temporarily stop, or permanently stop treatment with REZUROCK if you have certain side effects.
REZUROCK may affect fertility in males and females. Talk to your healthcare provider if this is a concern for you.
These are not all the possible side effects of REZUROCK. Call your doctor for medical advice about side effects.
Please see full Prescribing Information.
You are encouraged to report side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088. You may also contact Kadmon Pharmaceuticals, LLC, a Sanofi Company, at 1-800-633-1610 to report side effects.